1. Study the effect of yoga to prevent/delay the onset of diabetes in prediabetic subjects Prevalence of diabetes is increasing in Indian subcontinent. People are yet to gain knowledge about diabetes and related disorders. Widespread awareness is needed to be created among the general public about prevention of diabetes. So this study is focused to stress the importance of diet control, physical activity, walking and yoga in delaying the onset of diabetes in prediabetic subjects who have a positive family history of diabetes. The study was planned for 2 years from 2008 to 2010 with 1 year and 2 year follow ups. Subjects with elevated GTT values at fasting, 1 hour or 2 hour are selected and divided into groups. Group1 for control (standard care advice given), Group 2 for yoga therapy and Group 3 for LSM (diet & exercise). Anthropometric measurements are taken, biochemical details like GTT values, Lipid profile and HbA1c details will be collected. Plasma and serum samples are collected and stored for estimation of biochemical markers. Subjects are motivated for diet control and physical activity, walking and yoga, during baseline visit and follow-ups. Finally at the end of 2nd year the final data collection for anthropometric and biochemical details will be done. Out come of the study will be assessed by comparing baseline and 1 year and 2 year follow up details. 2. To study the effect of Yoga / OHA on newly diagnosed diabetic subjects This study was planned to study the effect of Yoga / OHA on newly diagnosed diabetic subjects. Newly diagnosed subjects who are not under any medications previously and those subjects who are diagnosed positive for diabetes in this center are selected. They are divided into two groups. Group1 is Yoga and Group 2 is OHA + Yoga. Baseline data will be collected and the subjects are followed after 3 months. Baseline anthropometric measurements, biochemical details like plasma glucose, lipid profile, and HbA1c, urea, creatinine details are collected. During follow-ups motivation will be done for yoga and diet control, biochemical details and anthropometric details are collected. 3. To study the effect of Metformin intervention in the treatment of metabolic syndrome Metabolic syndrome is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. It affects one in five people, and prevalence increases with age. The dominant underlying risk factors for this syndrome appear to be abdominal obesity and insulin resistance. Other conditions associated with the syndrome include physical inactivity, aging, hormonal imbalance and genetic predisposition. Individuals in prediabetic states such as IGT and EGI (elevated intermediate glucose response during OGTT) are at high risk of developing both type2 diabetes and cardiovascular diseases. The study was planned for 2 years from 2009 to 2011. Prediabetic subjects with EGI or IGT are randomly selected based on IDF criteria for metabolic syndrome and were divided into groups. Group1 Control, Group 2 Life style modification and Group 3 metformin. Details of demography, baseline anthropometric parameters like height, weight, waist, hip measurements, body fat % and daily calorie intake are taken. Biochemical investigations like plasma glucose, lipid profile, urea, creatinine and insulin are measured. Annually, OGTTs, anthropometric, lipid profile, blood pressure measurements will be taken. Outcome will be assessed at the end of the second year. For more info visit us: http://www.mvdiabetesbangalore.in
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