INTRODUCTION: The hydroxamic acid based HPCs are the powerful inhibitors of the affinity purified HDAC enzymes. These molecules can cause the collection of acetylated histones in the treated cells [1]. Few of the examples of this group include SAHA, which fits into the crystalline pocket of this enzyme. The zinc ion binds with the hydroxamic acid at the bottom of this pocket and makes it possible to inhibit the HDAC activity [2]. Pyroxamide PYROXAMIDE ACTIONS AND PERFORMANCE: Pyroxamide, syberoyl-3-aminopyridineamide hydroxamic acid, is one of the new members of the group of hydroxamic acid-based compounds. It is the powerful inhibitor of HDAC in transformed cells. It should be remembered that every molecule that comes in this class has different structures and functions [3]. Some of them are associated with the dissimilar solubility, while some of them possess different potency, and other properties. Hence the utilization of every molecule depends upon their structural and functional variations. PYROXAMIDE FOR PROSTATE CANCER: Pyroxamide has the property to induce the terminal differentiation of MEL cells and inhibition of the growth of various human transformed cell types in cultures at a very low concentration. The research studies on small animals have demonstrated that Pyroxamide can retard the growth of human prostate cancers. These findings were obtained when the xenografts of these cancer cells have been grown in mice. PYROXAMIDE FURTHER ACTIONS: Pyroxamide is a powerful inhibitor of affinity purified HDAC1. It has been observed that Pyroxamide can induce the accumulation of acetylated histones in the culture of MEL cells. In addition to that, such type of accumulation of acetylated histones was also observed in prostate tumors that have been removed from mice. Studies have shown the increased level of p21/WAF in mice that have been treated by means of Pyroxamide in order to inhibit the growth of grafted tumor cells in them. All of these results show that Pyroxamide is a useful molecule for treating malignancies. PYROXAMIDE RESEARCH STUDIES: Hydroxamic acid-based HPC, Pyroxamide is considered a potent and powerful molecule for retarding and inhibiting the growth of tumor cell growth inside and outside the body. This molecule can induce the suppression of growth of transformed prostate, bladder and neuroblastoma cells at a very low concentration. It has been observed during experiments when Pyroxamide is injected inside the mice, the prostate cancer cells have attained significant suppression and retardation. In addition to that, the molecule has developed very little detectable toxicity inside the body. Hence it can be used without the danger of having serious adverse reactions. The only two significant toxicities that have been observed by the use of Pyroxamide are the weight loss and postmortem necropsies. PYROXAMIDE PSA LEVEL: However, the PSA level does not decrease or remains unchanged by the usage of Pyroxamide. It does not mean that the effects are Pyroxamide are temporary and ineffective. It should be remembered that there are various anti-tumor molecules, that are significant and that can retard the growth of prostate cancer effectively. However, like Pyroxamide, they do not bring any change in the PSA levels [4 and 5]. CONCLUSION: In conclusion, there are various organizations and institutions that have chosen the Pyroxamide as a leading compound in the belt of anti-tumor molecules, which are used against various cancers including cancer of prostate, etc. REFERENCES: 1. Proc. Natl.Acad. Sci. USA, 95: 30033007, 1998. 2. Nature (Lond.), 401: 188193, 1999. 3. J. Natl. Cancer Inst. (Bethesda), 92: 12101216, 2000. 4. J. Cell. Biochem., 69: 271281, 1998. 5. Int. J. Oncol., 14: 501508, 1999.
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