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Therapeutic Efficacy Of The Pan-cdk Inhibitor Pha-793887 In Vitro And In Vivo In Engraftment And Hig

By: Dr. Jenny Home | Health-and-Fitness | High-Blood-Pressure


PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. The application of PHA793887 revealed that PHA793887 has strong antineoplastic activity at low does. Additionally, this inhibitor has potential activity in mice model.

Regardless of any specific chromosomal aberration, in vitro, PHA-793887 was cytotoxic for leukemic cell lines, with IC50 ranging from 0.3 to 7M (mean: 2.9M). Contrastively, the drug was not cytotoxic for CD34+ hematopoietic stem cells or unstimulated peripheral blood mononuclear cells at these doses. PHA-793887 showed very high activity against leukemia cell lines in colony assays, with an IC50



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