Diabetes can affect many parts of the body, including the kidneys. In healthy kidneys, many tiny blood vessels filter waste products from your body. The blood vessels have holes that are big enough to allow tiny waste products to pass through into the urine but are still small enough to keep useful products (such as protein and red blood cells) in the blood. High levels of sugar in the blood can damage these vessels if Diabetes is not controlled. This can cause kidney disease, which is also called nephropathy. If the damage is bad enough, your kidneys could stop working and develop to Renal Failure. According to the statistics of US, about 40% of Renal Failure is caused by Diabetes and in China it is 15% and is still rising. For patients with Diabetic Nephropathy, the kidneys are in the state of high perfusion, high filtration and high pressure, thus causing glomerulosclerosis. In order to control the illness condition of Diabetes, we have to effectively regulate the blood sugar, blood fat and blood pressure. The medicine for Diabetic Nephropathy are ACEI and ARB. One kind of it is used or both are used in combination. These medicine play an important role in controlling blood pressure, lowering proteinuria and protecting the kidneys and are the medications for Diabetes realized in the world. There are also suitable Chinese medicine in treating Diabetic Nephropathy. Shijiazhuang Kidney Disease Hospital in China uses Micro-Chinese Medicine Osmotherapy to treat Diabetic Nephropathy. It is a kind of externally used medicine. It avoided the side effects of oral taking medicine and will not go through the digestive system, so the absorption rate has been greatly improved. There are mainly four functions of this kind of treatment that is expanding blood vessels so as to improve blood circulation, anti coagulation, anti inflammation and repair and degrading extracellular matrix deposited on the basement membrane. After the internal environment of the body has been improved, we can use stem cells to repair the damaged beta cells of the islet so as to make it secrete insulin normally. Diabetic Nephropathy is a complication of DMIP which is caused by Diabetes. Renal function can by reversed by proper treatment in the early stage of Diabetic Nephropathy. If Diabetic Nephropathy develop into Renal Failure or Uremia, this treatment will spend more time, money, and worst of all, the disease can’t be cured. Therefore, it is very important to choose a proper treatment in the early stage of Diabetic Nephropathy. Firstly, we need to understand the stages of Diabetic Nephropathy. That is because different stage has different treatment. 1. Glomerular filtration stage: it is featured by increasing glomerular filtration rate and enlarging the size of kidney. These changes accompany with high blood sugar. With the help of insulin treatment, the disease can be reversed in this stage, but can’t recover completely. 2. Kidney damage stage without any symptoms: this stage is featured by normal proteinuria discharge rate and changed glomerular structure. 3. The early stage of Diabetic Nephropathy: the discharge rate of albumin is 20--200g/ min, patients present a slightly increased blood pressure and glomerulus begin to necrosis. 4. This stage is featured by a lot of albuminuria(>3.5g everyday),edema and high blood pressure. Diuretic medicines have little effect for patient’s edema in this stage. 5. The late/end stage of renal failure: because glomerular basement membrane become more and more thick, blood capillary become more and more narrow, more and more glomeruli begin to necrosis/ sclerosis. In the end, the filtration function decrease gradually, which leads to Renal Failure.
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