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Cp690550, A Potent Anti-inflammatory Agent By : Huang
Asthma is a common chronic inflammatory disease whose pathogenesis has been attributed to multiple cell types. Due to the ability to suppress multiple inflammatory genes that contribute to asthma, corticosteroids have long been important drugs for asthma therapy. However, their beneficial effects do not apply to all patient ...
Keywords: abt-869, amg706, av-951, belinostat
Ifns Provide New Approaches In Hcv Treatment By : Huang
4% of the world's people are infected with Hepatitis C virus (HCV), and some of them will develop cirrhosis or even hepatocellular carcinoma within 20 to 30 years of infection. Therefore, HCV has become a serious threat to human health. The combination of IFN and ribavirin (RBV) has been the standard treatment for pa ...
Keywords: fty720, gsk1363089, hdac inhibitors, imatinib
Bibw2992 By : Huang
BIBW2992 is a highly potent, irreversible dual EGFR/HER2 tyrosine kinase inhibitor potentially efficacious in the treatment of cancers dependent on EGFR/HER2 signaling.

Keywords: ruxolitinib, sb-431542, screening library, vorinostat
Bibw2992 Fgfr Activated By Neural Cell Adhesion Molecule By : Huang
FGFR can be activated by not only FGFs,but also neural cell adhesion molecule (NCAM). NCAM is a homophilic binding glycoprotein mainly expressed on the surface of neurons.NCAM is thoughtl to induce neurite outgrowth via the FGFR signaling pathway.

Keywords: compound libraries, enzastaurin, foretinib, kinase inhibitor
Dasatinib By : Huang
The resistence to Imatinib is the most problem to the treatment of CML. By a deep research of the drug-resistant mechanism, the second generation tyrosine kinase inhibitor represented by Dasatinib and Nilotinib is applied in clinical treatment of CML resistant to Imatinib.

Keywords: dasatinib, apoptosis inhibitors, bortezomib, bsi-201
Cudc-101: Single Molecule For Various Cancers In The Body By : leoon
Receptor tyrosine kinase inhibitors have become more significant in these days in order to halt the growth of cancers and malignant tumors. There are various cancers, which can be prevented by means of this pathway. The noteworthy point is that, every cancer exhibits diversity and variation in its propagation and growth.
Keywords: bortezomib bsi-201 dasatinib enzastaurin foretinib kinase inhibitor
Recommendations In Making Sure Your Glass Is Squeaky Clean By : Jennifer Daniel
As with everything else that is of great importance to people, keeping it clean and proper maintenance are some of the challenges that end users always face. True after a new SUVs delivery is the daunting task of making the vehicle as long five or ten years. With glass and other materials with glass, keeping the glass clear ...
Keywords: anti fog cleaner, anti fog
Tivozanib-for-treating-renal-cell-carcinoma/ By : wu
The inhibitor of receptor tyrosine kinase (RTK) is being developed by two pharmaceutical company Aveo and Astellas to treat solid tumor. Tivozanib is now under phase III clinical trial for the treatment of advanced renal cell carcinoma (RCC) based on its good results from phase II clinical trial.
Keywords: receptor tyrosine kinasetivozanib
Molecular Mechanism Of Pd98059 By : rabia
PD98059, having the structural formula [2-(2�-amino-3�-methoxyphenyl)-oxanaphthalen-4-one] is a potent and flavonoid inhibitor of MEK (mitogen-activated protein kinase). PD98059 in a concentration of less than or equal to 20 uM does not produce cytotoxicity in the cultures of the human breast epithelial lines of cells, ...
Keywords: mapkblog.com pd98059 inhibitor of mek
A New Potent And High Selective Mtor Inhibitor With Better Stability Of Mouse Liver Microsome By : KenZhang
A new potent and high selective mTOR inhibitor with better stability of mouse liver microsome stability was discovered by Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School. They report this discovery on the Bioorganic & Medicinal Chemistry Letters.
Keywords: pi3kaktblog.com mtor inhibitor
Bibf1120 Is Under Phase I Clinical Trial For Small Cell Lung Cancer Patients By : wu
Non-small cell lung cancer (NSCLC) is the most common cancer type in lung cancers and causes most motality for all the lung cancers. Fortunately, several inhibitors of epidermal growth factor receptor have the clinical application for treating this disease such as Gefitinib and Lapatinib, which were under clinical trial for ...
Keywords: apoptosis-inhibitors.com, non-small cell lung cancer
Parp Inhibitors Has A Great Prospect For Brca Deficient Cancer Patients By : song
In the recent research many parp inhibitors could prolong survival by blocking single-strand DNA repair in the BRCA mutant or deficient cancer cells. TheDNA breaking often cause by radiation and some chemotherapies.
BRCA gene code the breast cancer type 1 susceptibility protein, which plays an important role in double ...
Keywords: parpforresearch.com, parp inhibitors
Jnj-26481585: Smart Molecule With Great Uses By : leoon
Histone deacetylase or HDAC inhibitors are famous for their induction of arrest of cell cycle, apoptosis in various tumors found in man, and the terminal differentiation
Keywords: hdacblog.com, hdac inhibitors
Plk Inhibitor Bi 2536 In Drug Resistance By : Jone
PLKs are major targets for cancer therapy in cell cycle pathway. It plays a role in cell cycle pregression, mitosis and checkpoint control. When chromosomal instability, DNA aneuploidy or centrosome amplification occurs, the express of PLK proteins may up-regulated. Some studies identified cancer cells are more sensitive to ...
Keywords: cell cycle inhibitors, polo-like kinases (plks)
Oncogenic Jak-activating Mutations,can Be Used To Evaluate Jak Inhibitors By : Jake
The V617F mutation of JAK2 is the first identified activating mutation caused by the disease, found in patients with myeloproliferative neoplasms (MPNs). Several JAK2 inhibitors targeted to JAK2 V617F are now under study for clinical trials of MPNs.
Keywords: incb018424 egfr
Inhibitory Effects Of Mubritinib (tak 165) On Her2 In Vitro By : Huang
TAK-165 is also named as mubritinib which is first originally designed and synthesized by Takeda Chemical Industries in Japan. Mubritinib (TAK 165) (view Fig. 1 for its chemical structure) is validated as a potent human epidermal growth factor receptor 2 (HER2; erbB2) that is classified into one of members of epidermal grow ...
Keywords: angiogenesis-inhibitorstak-165
Sp600125 Molecular Mechanism And Significance By : rabia
SP600125 is an anthrapyrazolone series reversible ATP-competitive inhibitor, which can significantly inhibit the JNK 1, 2 and 3. This molecule possesses more than 20 folds increased selectivity as compared to the other molecules and enzymes that have been tested for the same purpose.
Keywords: mapkblog.com jnk sp600125
Which Targets To Hit For Pi3k Pathway? Selective Inhibitors Or Dual Inhibitors? By : KenZhang
Vanhaesebroeck,the head of the Centre for Cell Signalling at Barts Cancer Institute:
The big hit came in 2004,with the discovery of the oncogenic mutation of PIK3CA,the gene that encodes the PI3K catalytic subunit p110.

Keywords: pi3kaktblog.com pi3k inhibitors
The Overview Of Targeting Egfr For Solid Tumor 3 By : wu
Cetuximab is currently under phase II clinical trial in Europe for metastatic colorectal cancer (mCRC). To evaluate the effectiveness of cetuximab monotherapy on mCRC, 346 patients with mCRC refractory to both irinotecan and oxaliplatin were treated with cetuximab.
Keywords: apoptosis-inhibitors.com, colorectal cancer
Parp Inhibitor Ino-1001 Has A Universal Use In The Different Diseases By : song
INO-1001 is a novel PARP inhibitor, which is produced by Inotek Pharmaceuticals Corp. A lot of studies reveal its heartening functions in various disease models.

Keywords: parpforresearch.com, ino-1001 inhibitors
Entinostat - A Powerful Molecule Against Blood Cancers By : leoon
The subsequent administration of DNA methyltransferase (DNMT) inhibitors and Histone deacetylase HDAC inhibitors has significant effectiveness against blood cancers. Nevertheless the mechanisms behind these actions are still a controversial issue.
Keywords: hdacblog.com, histone deacetylase hdac inhibitors
Nms-p937 Is A New Plk1 Inhibitor By : Jone
PLK1 plays a key role in the mitotic entry, centrosome duplication, bipolar mitotic spindle formation, transition from metaphase to anaphase, cytokinesis and maintenance of genomic stability.
Keywords: cell cycle inhibitors, plk inhibitors
Vitamin A Circulation May Be A Important Target In Obesity Treatment By : Jake
Obesity is a medical condition as abnormal or excessive fat accumulation. Obesity is a potential risk factor causing various diseases, such as heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. In 2005, the WHO estimates that at least 400 million adults (9.8%) are obese, w ...
Keywords: jak2 jak/stat signaling pathway
Synergistic Inhibitory Effects Of Cudc-101 By : Huang
CUDC-101 is a multitargetd small-molecular compound which is a potent receptor tyrosine kinase (including EGFR and HER2 et al.) and histone deacetylase (including calss I and class II) inhibitor with extremely low half-inhibitory concentration up to nanomole.

Keywords: angiogenesis-inhibitorscudc-101
The Overview Of Targeting Egfr For Solid Tumor 2 By : wu
In my last blog, I analyzed the overall mechanism of the EGFR inhibitors for treating solid tumors. The inhibition of EGFR includes monoclonal antibody and tyrosin kinase inhibitors. Cetuximab (Erbitux) is the most popular monoclonal antibody of EGFR and had been approved for marketing in many countrys. Cetuximab is used to ...
Keywords: apoptosis-inhibitors.com, cetuximabegfr inhbitor

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