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    By: Bruce Forciea | May 23rd 2007
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    By: leoon | Sep 1st 2011
    Histone deacetylases (HDAC) (EC number 3.5.1) are a class of enzymes that remove acetyl groups (O=C-CH3) from an -N-acetyl lysine amino acid on a histone. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
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  • Cudc-101 Exerts Its Potent Antiproliferative Activity Via Inhibition Of Multiple Signaling Pathways
    By: Huang | Sep 2nd 2011
    Recent studies suggested that CUDC-101 indirectly attenuates the survival Akt signaling pathway, HER3 signaling pathway, and MET signaling pathway in addition to directly inhibiting both EGFR and HER2 signaling pathways.
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  • Entinostat - A Powerful Molecule Against Blood Cancers
    By: leoon | Sep 4th 2011
    The subsequent administration of DNA methyltransferase (DNMT) inhibitors and Histone deacetylase HDAC inhibitors has significant effectiveness against blood cancers. Nevertheless the mechanisms behind these actions are still a controversial issue. Read

  • Jnj-26481585: Smart Molecule With Great Uses
    By: leoon | Sep 5th 2011
    Histone deacetylase or HDAC inhibitors are famous for their induction of arrest of cell cycle, apoptosis in various tumors found in man, and the terminal differentiation Read

  • Cudc-101: Single Molecule For Various Cancers In The Body
    By: leoon | Sep 9th 2011
    Receptor tyrosine kinase inhibitors have become more significant in these days in order to halt the growth of cancers and malignant tumors. There are various cancers, which can be prevented by means of this pathway. The noteworthy point is that, every cancer exhibits diversity and variation in its propagation and growth. Read

  • Dasatinib
    By: Huang | Sep 16th 2011
    The resistence to Imatinib is the most problem to the treatment of CML. By a deep research of the drug-resistant mechanism, the second generation tyrosine kinase inhibitor represented by Dasatinib and Nilotinib is applied in clinical treatment of CML resistant to Imatinib.

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  • Bibw2992 Fgfr Activated By Neural Cell Adhesion Molecule
    By: Huang | Sep 16th 2011
    FGFR can be activated by not only FGFs,but also neural cell adhesion molecule (NCAM). NCAM is a homophilic binding glycoprotein mainly expressed on the surface of neurons.NCAM is thoughtl to induce neurite outgrowth via the FGFR signaling pathway.

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  • Bibw2992
    By: Huang | Sep 16th 2011
    BIBW2992 is a highly potent, irreversible dual EGFR/HER2 tyrosine kinase inhibitor potentially efficacious in the treatment of cancers dependent on EGFR/HER2 signaling.

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  • Ifns Provide New Approaches In Hcv Treatment
    By: Huang | Sep 20th 2011
    4% of the world's people are infected with Hepatitis C virus (HCV), and some of them will develop cirrhosis or even hepatocellular carcinoma within 20 to 30 years of infection. Therefore, HCV has become a serious threat to human health. The combination of IFN and ribavirin (RBV) has been the standard treatment for patients with chronic HCV infection. However, it can have a positive effect on only half of the treated individuals, and produce some significant side effects. Read

  • Itf2357 †An Inhibitor Showing Multifarious Effects
    By: Dr. Jenny | Dec 16th 2011
    Certain forward and backward modifications are facilitated by a set of enzymes which are known as HATs and HDACs. They maintain a balanced acetylation of the histone proteins. A decrease in the quantity of HATs leads to excess deacetylation of histone proteins. This further stimulates the neuronal degeneration. HDAC inhibitors like Valporate, Vorinostat and ITF2357 help in treating neuronal disorders. Read

  • Mc1568 †Helps In The Analysis Of The Action Of Class Ii Hdacs
    By: Dr. Jenny | Dec 20th 2011
    The discovery of the role of HDACs within cancer has promoted the synthesis of inhibitors to HDACs which show a targeted action within the cancer cells. The primary role of HDACs is the regulation of the formation of heterochromatin. It deacetylates the histones and enables the chromatin to attain a more compact form. Some HDAC enzymes also target non histone proteins like NFB and p53. The targeted action of HDAC inhibitors can be understood well with the help of Vorinostat which selectively t ... Read

  • Biophysical Assay Methods In Hts
    By: rabia | Dec 22nd 2011
    The key strategy of drug development in the contemporary era involves the screening of compound libraries. The process of HTS becomes useful only when the results of screening analysis are visualized. This visualization is accomplished by performing high quality HTS assays which employ certain radioactive, fluorescence or other biophysical methods to see the changes. Assay methods have to be developed and optimized according to the need of experiment. Knowledge of basic principles of varying arr ... Read

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